N-(cyclopropylmethoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5-a]pyrazine-6-carboxamide → 5-(4-Bromo-2-fluorophenylamino)-N-(cyclopropyl-methoxy)imidazo[1,5-a]pyrazine-6-carboxamide

HRID 167275Notes

Reaction equation

HRID 167275 reaction equation
[CH3:27][O:28][C:29]([c:30]1[n:31][cH:32][c:33]2[n:34]([cH:35][n:36][cH:37]2)[c:38]1[NH:39][c:40]1[cH:41][cH:42][c:43]([Br:44])[cH:45][c:46]1[F:47])=[O:48].[CH:1]1([CH2:4][O:5][NH:6][C:7](=[O:8])[c:9]2[n:10][cH:11][c:12]3[n:13]([c:14]2[NH:15][c:16]2[c:17]([F:23])[cH:18][c:19]([I:22])[cH:20][cH:21]2)[cH:24][n:25][cH:26]3)[CH2:2][CH2:3]1>>[CH:1]1([CH2:4][O:5][NH:6][C:7](=[O:8])[c:9]2[n:10][cH:11][c:12]3[n:13]([c:14]2[NH:15][c:16]2[c:17]([F:23])[cH:18][c:19]([Br:44])[cH:20][cH:21]2)[cH:24][n:25][cH:26]3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 44135983N-(cyclopropylmethoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5-a]pyrazine-6-carboxamideHCID 591401755-(4-Bromo-2-fluoro-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid methyl ester

Product 1

HCID 441361065-(4-Bromo-2-fluorophenylamino)-N-(cyclopropyl-methoxy)imidazo[1,5-a]pyrazine-6-carboxamide

Sources & evidence

ORD record
ord-f8c9c53cdfb84d6ba2cf961e8971128f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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