Hydroxide → HCID 25127534, compound

Participants

Reaction Steps

Compound 24 (1.05 g, 2.52 mmol) obtained in Example 24 was dissolved in methanol (10 mL), and the mixture was stirred at room temperature for 1 hour after adding BIO RAD AG 1-X8 Resin (BIO RAD; AG 1-X8 resin, 20-50 mesh, hydroxide form). The reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure to give (S)-9-ethylamino-5-(piperidin-4-yl)methyl-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (890 mg, quantitative).

Provenance & Evidence