Water → HCID 25102817, compound

Participants

Reaction Steps

Compound 32 (800 mg, 1.92 mmol) obtained in Example 32 was suspended in dichloromethane (15 mL), and the mixture was stirred at room temperature for 4 hours after adding N,N-diisopropylethylamine (1.16 mL, 6.71 mmol) and 2-furoyl chloride (226 μL, 2.30 mmol). Thereafter, water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The resulting residue was purified by silica gel column chromatography, and crystallized from diethyl ether to give the title compound (Compound 35) (601 mg, 71%).

Provenance & Evidence