1-Acetylpiperazine → HCID 67352325, compound

Participants

Reaction Conditions

Reaction Steps

Compound 21 (90.0 mg, 0.223 mmol) obtained in Example 21 was dissolved in a mixed solvent of 1,4-dioxane (4 mL) and tert-butyl alcohol (2 mL), and the mixture was stirred at 80° C. for 1.5 hours after adding 1-acetylpiperazine (57.0 mg, 0.446 mmol), tris(dibenzylideneacetone)dipalladium (41.0 mg, 0.0446 mmol), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (53.0 mg, 0.134 mmol), and sodium tert-butoxide (43.0 mg, 0.446 mmol). The mixture was filtered through sellite, and the residue obtained by concentrating the filtrate was purified by silica gel column chromatography to give the title compound (Compound 40) (34.0 mg, 34%).

Provenance & Evidence