Ethanol hydrochloride → HCID 67350105, compound

Participants

Reaction Steps

(S)-5-[5-(4-Tert-butoxycarbonylpiperazine-1-yl)pyridin-3-yl]-9-ethylamino-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (104 mg, 0.204 mmol) obtained in Step 1 was dissolved in ethanol (2 mL), and the mixture was stirred at room temperature for 1.5 hours after adding 4 mol/L hydrochloric acid-ethanol (3 mL). After concentrating the mixture, a saturated aqueous sodium bicarbonate solution was added, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give (S)-9-ethylamino-5-[5-(piperazine-1-yl)pyridin-3-yl]-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (56.1 mg, 68%).

Provenance & Evidence