Formaldehyde → HCID 25127537, compound

Participants

Reaction Steps

(S)-9-Ethylamino-5-[5-(piperazine-1-yl)pyridin-3-yl]-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (56.1 mg, 0.137 mmol) obtained in Step 2 was dissolved in 1,2-dichloroethane (4 mL), and the mixture was stirred at room temperature for 1 hour after adding 37% formalin solution (0.0310 mL, 0.411 mmol) and sodium triacetoxyborohydride (87.0 mg, 0.411 mmol). Thereafter, a saturated aqueous sodium bicarbonate solution was added to the mixture, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (Compound 42) (43.0 mg, 74%).

Provenance & Evidence