Hydrazine → HCID 67348885, compound

Participants

Reaction Conditions

Reaction Steps

Compound 18 (1.15 g, 2.19 mmol) obtained in Example 18 was dissolved in ethanol (11 mL), and the mixture was stirred overnight at 80° C. after adding hydrazine.monohydrate (1.06 mL, 21.9 mmol). The mixture was concentrated, diluted with chloroform, and washed with water. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give (S)-3-(9-ethylamino-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)benzoic hydrazide (1.10 g, quantitative).

Provenance & Evidence