Dimethylformamide → HCID 86643697, compound

Participants

Reaction Steps

(S)-3-(9-Ethylamino-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)benzoic hydrazide (220 mg, 0.576 mmol) obtained in Step 1 was dissolved in DMF (2.3 mL), and the mixture was stirred overnight at room temperature after adding phenylacetyl chloride (0.115 mL, 0.867 mmol) and triethylamine (0.161 mL, 1.15 mmol). After concentrating the mixture, the resulting residue was purified by silica gel column chromatography to give (S)-3-(9-ethylamino-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)benzoic acid-N′-phenyl-acetyl hydrazide (191 mg, 66%).

Provenance & Evidence