Sodium Hydroxide → HCID 67350552, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (S)-3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)benzoate (1.85 g, 4.64 mmol) obtained in Step 1 of Example 18 was dissolved in ethanol (23 mL), and the mixture was stirred at 90° C. for 1 hour after adding a 10% aqueous sodium hydroxide solution (1.7 mL, 46.4 mL). After concentrating the mixture under reduced pressure, a 10% aqueous hydrochloric acid solution was added and stirred. The precipitated solid was filtered off and dried to give (S)-3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)benzoic acid (1.36 g, 79%).

Provenance & Evidence