Dimethylamine tetrahydrofuran → HCID 67350530, compound

Participants

Reaction Steps

Methyl (S)-3-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,2,4-oxadiazole-5-carboxylate (162 mg, 0.36 mmol) obtained in Step 1 of Example 80 was dissolved in THF (3.0 mL), and the mixture was stirred at room temperature for 2 hours after adding a 2.0 mol/L dimethylamine/THF solution (1.80 mL, 3.58 mmol). The residue obtained by concentrating the mixture under reduced pressure was then purified by silica gel column chromatography to give (S)—N,N-dimethyl 3-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,2,4-oxadiazole-5-carboxamide (151 mg, 90%).

Provenance & Evidence