Sodium Hydroxide → HCID 67352389, compound

Participants

Reaction Conditions

Reaction Steps

(S)-{3-[3-(9-Methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,2,4-oxadiazol-5-yl}methyl acetate (529 mg, 1.13 mmol) obtained in Step 1 was dissolved in ethanol (6.0 mL), and the mixture was stirred at 60° C. for 2 hours after adding a 3 mol/L aqueous sodium hydroxide solution (4.0 mL). After concentrating the mixture under reduced pressure, water was added to the resulting residue. The precipitated white solid was filtered off, and purified by silica gel column chromatography to give (S)-5-[3-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)phenyl]-9-methylthio-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (234 mg, 49%).

Provenance & Evidence