Ammonia methanol → HCID 67350635, compound

Participants

Reaction Steps

Methyl (S)-3-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,2,4-oxadiazole-5-carboxylate (320 mg, 0.71 mmol) obtained in Step 1 of Example 80 was dissolved in methanol (3.0 mL), and the mixture was stirred at room temperature for 3 hours after adding a 2.0 mol/L ammonia/methanol solution (3.50 mL, 7.07 mmol). The residue obtained by concentrating the mixture under reduced pressure was then purified by silica gel column chromatography to give (S)-3-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,2,4-oxadiazole-5-carboxamide (300 mg, 96%).

Provenance & Evidence