HCID 67350115, compound → HCID 67352803, compound

Participants

Reaction Conditions

Reaction Steps

(S)-5-[3-(9-Methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,3,4-oxadiazol-2(3H)-one (140 mg, 0.34 mmol) obtained in Step 1 of Example 89 was suspended in 2-methyl-2-oxazoline (1.0 mL), and the mixture was stirred overnight at 100° C. The residue obtained by concentrating the mixture under reduced pressure was then purified by silica gel column chromatography to give (S)—N-(2-{5-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-2-oxo-1,3,4-oxadiazol-3(2H)-yl}ethyl)acetamide (226 mg, quantitative).

Provenance & Evidence