Lawesson's reagent → HCID 86643701, compound

HRID 1672813Notes

Reaction equation

HRID 1672813 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:21])=CC=1>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[S:21]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 6157743-Iodobenzohydrazide

Product 1

HCID 86643701HCID 86643701, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Iodobenzohydrazide (500 mg, 1.91 mmol) obtained in Step 1 of Example 52 was suspended in toluene (10 mL), and the mixture was refluxed for 1 hour after adding Lawesson's reagent (772 mg, 1.91 mmol). The mixture was then purified by silica gel column chromatography to give 3-iodothiobenzohydrazide (391 mg, 74%).

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customThe mixture was then purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d433ef6b86d44c6db92c2bb892b2bbb0
Source dataset
uspto-grants-2011_08
Patent number
US07998954B2

Reaction notes

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