Pyridine → HCID 19170012, compound

HRID 1672815Notes

Reaction equation

HRID 1672815 reaction equation
[I:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].N1C=CC=CC=1.[C:18](Cl)(=[O:20])[CH3:19]>ClCCl>[C:18]([NH:7][NH:6][C:4](=[O:5])[C:3]1[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=1[I:1])(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 6156752-Iodobenzohydrazide

Product 1

HCID 19170012HCID 19170012, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

2-Iodobenzohydrazide (1.38 g, 5.27 mmol) obtained in Step 1 of Example 114 was dissolved in dichloromethane (50 mL), and the mixture was stirred at 0° C. for 1.5 hours after adding pyridine (0.639 mL, 7.90 mmol) and acetyl chloride (0.412 mL, 5.79 mmol). The precipitated solid was filtered off, and the resulting solid was dried under reduced pressure to give N′-acetyl-2-iodobenzohydrazide (1.23 g, 77%).

Workup

  1. filtrationThe precipitated solid was filtered off
  2. customthe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-964784db775d4e29a25e91b4cee09636
Source dataset
uspto-grants-2011_08
Patent number
US07998954B2

Reaction notes

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