HCID 67351694, compound → HCID 86643702, compound

Participants

Reaction Steps

(S)-5-(3-Hydroxymethylphenyl)-9-methylthio-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (100 mg, 0.280 mmol) obtained in Step 1 was dissolved in dichloromethane (10 mL), and the mixture was stirred overnight at room temperature after adding manganese dioxide (366 mg, 4.21 mmol). The mixture was filtered through sellite, and the filtrate was collected, concentrated, and purified by silica gel column chromatography to give (S)-5-(3-formylphenyl)-9-methylthio-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (77.8 mg, 78%).

Provenance & Evidence