Sulfuric Acid → HCID 67350132, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated sulfuric acid (13 mL) was added to 3-iodo-N-(2-oxopropyl)benzamide (1.33 g, 4.39 mmol) obtained in Step 2, and the mixture was stirred at 100° C. for 1.5 hours. The mixture was poured into iced water, neutralized with a 4 mol/L aqueous sodium hydroxide solution, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was then purified by silica gel column chromatography to give 2-(3-iodophenyl)-5-methyl-1,3-oxazole (1.20 g, 96%).

Provenance & Evidence