Bromotrichloromethane → HCID 67348230, compound

Participants

Reaction Steps

Methyl (S)-2-{3-[(S)-9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl]phenyl}-4,5-dihydro-1,3-oxazole-4-carboxylate (138 mg, 0.304 mmol) obtained in Step 1 was dissolved in dichloromethane (5 mL), and the mixture was stirred at room temperature for 2 hours after adding bromotrichloromethane (0.181 mL, 0.913 mmol) and diazabicyclo[5,4,0]undec-7-ene (0.137 mL, 0.913 mmol). The mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to give methyl (S)-2-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,3-oxazole-4-carboxylate (119 mg, 87%).

Provenance & Evidence