Sodium Hydroxide → HCID 67348673, compound

Participants

Reaction Steps

Methyl (S)-2-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,3-oxazole-4-carboxylate (172 mg, 0.381 mmol) obtained in Step 2 of Example 123 was dissolved in ethanol (3 mL), and the mixture was stirred at room temperature for 1.5 hours after adding a 2 mol/L aqueous sodium hydroxide solution (1.90 mL, 3.81 mmol). The mixture was concentrated, diluted with water, and neutralized with 1 mol/L hydrochloric acid. The precipitated solid was then filter off, and dried overnight under reduced pressure to give (S)-2-[3-(9-methylthio-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenyl]-1,3-oxazole-4-carboxylic acid (110 mg, 66%).

Provenance & Evidence