反应详情

5-Hydroxymethyl-2-(3-iodophenyl)-1,3-oxazole (747 mg, 2.48 mmol) obtained in Step 2 of Example 122 was dissolved in dichloromethane (30 mL), and the mixture was stirred at room temperature for 2 hours after adding manganese dioxide (2.16 g, 24.8 mmol). The solid was separated by filtration through sellite. The filtrate was concentrated, and purified by silica gel column chromatography to give 5-formyl-2-(3-iodophenyl)-1,3-oxazole (678 mg, 91%).

1. customThe solid was separated by filtration through sellite
2. concentrationThe filtrate was concentrated
3. custompurified by silica gel column chromatography