Hydrochloric Acid → HCID 67351596, compound

Participants

Reaction Steps

(S)-5-(1-Tert-butoxycarbonyl-5-cyanoindole-3-yl)-9-ethylamino-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (25.0 mg, 0.0513 mmol) obtained in Step 4 was dissolved in ethanol (2 mL), and the mixture was stirred at room temperature for 30 minutes after adding a 2 mol/L aqueous sodium hydroxide solution (0.256 mL, 0.513 mmol). The mixture was neutralized with 1 mol/L hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was then purified by preparative TLC to give the title compound (Compound 140) (19.2 mg, 96%).

Provenance & Evidence