Triphenylphosphine → HCID 67348329, compound

Participants

Reaction Steps

3-Iodophenol (1.00 g, 4.55 mmol) and 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.37 g, 6.82 mmol) were dissolved in toluene (30 mL), and the mixture was stirred at room temperature for 1 hour after adding triphenylphosphine (1.79 g, 6.82 mmol) and a 40% toluene solution of diethyl azodicarboxylate (3.09 mL, 6.82 mmol). The mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to give 1-tert-butoxycarbonyl-4-(3-iodophenoxy)piperidine (1.81 g, 98%).

Provenance & Evidence