1,4-Dioxane hydrochloride → HCID 67351083, compound

Participants

Reaction Steps

(S)-1-Tert-butoxycarbonyl-4-(3-(9-ethylamino-6-oxo-2,3,3a,4-tetrahydro-1H,6H-5,8,10,10b-tetraazabenzo[e]azulen-5-yl)phenoxypiperidine (0.633 g, 1.21 mmol) obtained in Step 2 was dissolved in 1,4-dioxane (10 mL), and the mixture was stirred at room temperature for 1.5 hours after adding a 4 mol/L hydrochloric acid-1,4-dioxane solution (10 mL). The mixture was concentrated under reduced pressure, diluted with chloroform, and washed with a saturated aqueous sodium bicarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and crystallized from diethyl ether to give the title compound (Compound 147) (0.420 g, 82%).

Provenance & Evidence