Formaldehyde → HCID 67351671, compound

Participants

Reaction Steps

Compound 147 (100 mg, 0.237 mmol) obtained in Example 147 was dissolved in 1,2-dichloroethane (5 mL), and the mixture was stirred at room temperature for 2 hours after adding 37% formalin solution (0.0530 mL, 0.710 mmol) and sodium triacetoxyborohydride (150 mg, 0.710 mmol). Thereafter, a saturated aqueous sodium bicarbonate solution was added to the mixture, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and crystallized from diethyl ether to give the title compound (Compound 148) (93.9 mg, 91%).

Provenance & Evidence