Pyridine → HCID 67351296, compound

Participants

Reaction Conditions

Reaction Steps

Compound 147 (50.0 mg, 0.118 mmol) obtained in Example 147 was dissolved in dichloromethane (3 mL), cooled to 0° C., and stirred at 0° C. for 30 minutes after adding pyridine (0.0110 mL, 0.142 mmol) and acetyl chloride (0.0100 mL, 0.142 mmol). A saturated aqueous sodium bicarbonate solution was added to the mixture, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was then purified by preparative TLC to give the title compound (Compound 150) (54.2 mg, quantitative).

Provenance & Evidence