Ethanol hydrochloride → HCID 67348346, compound

Participants

Reaction Steps

(S)-5-[3-(4-Tert-butoxycarbonylpiperazine-1-yl)phenyl]-9-ethylamino-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (0.235 g, 0.643 mmol) obtained in Step 3 was dissolved in ethanol (3 mL), and the mixture was stirred at room temperature for 1 hour after adding 4 mol/L hydrochloric acid-ethanol (3 mL). The mixture was concentrated, and extracted with chloroform after adding a saturated aqueous sodium bicarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, and the residue obtained by concentrating the organic layer was purified by silica gel column chromatography to give (S)-9-ethylamino-5-[3-(piperazine-1-yl)phenyl]-1,2,3,3a,4,5-hexahydro-5,8,10,10b-tetraazabenzo[e]azulen-6-one (0.185 g, quantitative).

Provenance & Evidence