反应详情

A cis/trans mixture of ethyl (E)-3-(2-furyl)prop-2-enoate (15.5 g, 93.27 mmol, 1 eq) was stirred in ethanol (120 ml) containing 10% palladium on charcoal (775 mg, 5% by w). The reaction mixture was stirred under hydrogen for 4 h. A further quantity of 10% Pd/C (775 mg, 5% by w) was added. The reaction was stirred under hydrogen for an additional 95 mins. The reaction was filtered and evaporated under reduced pressure. The crude product was purified by silica column chromatography eluting with 20% ethyl acetate in hexanes. The desired fractions were evaporated under reduced pressure and ethyl 3-(2-furyl)propanoate was obtained as a clear oil (3.69 g, 24% yield).

1. stirringThe reaction was stirred under hydrogen for an additional 95 mins
2. filtrationThe reaction was filtered
3. customevaporated under reduced pressure
4. customThe crude product was purified by silica column chromatography
5. washeluting with 20% ethyl acetate in hexanes
6. customThe desired fractions were evaporated under reduced pressure