Potassium Carbonate → HCID 59240397, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol (0.26 g, 1 mmol), methyl bromoacetate (0.195 mL, 2 mmol) and K2CO3 (276 mg, 2 mmol) in acetonitrile (2 mL) was shaken overnight at 85° C. After cooling, solid was removed by filtration and washed with acetonitrile. The filtrate was evaporated to give a crude, which was purified by chromatography on silica gel eluting with EtOAc-Hexane (1:4) to give methyl {[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}acetate (180 mg). 1H-NMR (CDCl3): δ 7.52 (2H, m), 7.42 (2H, m), 5.91 (1H, s), 4.67 (2H, s), 3.80 (3H, s). MS (ES): 335 [M+H]+

Provenance & Evidence