Triethylamine → HCID 86640019, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of give 1-(3′-methylsulfonyl)biphenyl-4-yl)-2-(2-(trifluoromethyl)phenyl-1H-imidazole-4-carbonitrile (694 mg, 1.485 mmol), NH2OH.HCl (258 mg, 3.71 mmol), Et3N (0.6 mL, 4.3 mmol), and dry EtOH (15 mL) was stirred at 55° C. for 5 h under N2. The solvent was removed in vacuo to give N′-hydroxy-1-(3′-methylsulfonyl)biphenyl-4-yl)-2-(2-(trifluoromethyl)phenyl-1H-imidazole-4-carboximidamide as a white solid, which was used in the next reaction without further purification. MS (ESI) 501 [M+H]+.

Provenance & Evidence