Dichloromethane → Clopidogrel

Participants

Reaction Steps

Under the protection of nitrogen gas, clopidogrel hydrochloride (7.15 g) was introduced into methylene dichloride (100 ml) in a 250 ml flask under stirring and cooling with ice water. Then a solution of potassium carbonate (2.5 g) in de-ionized water (30 ml) was added drop by drop into the flask and it was stirred for one hour. The pH value of the upper aqueous phase was kept over 9. The lower organic phase was separated and the aqueous phase was extracted with methylene dichloride (50 ml). The organic phases were combined and dried over sodium sulfate and then concentrated to obtain a free clopidogrel base.

Provenance & Evidence