2-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-3-benzazepin-3-yl)-1-(4-methyl-piperazin-1-yl)-ethanone → 2-{7-[5-Chloro-4-(4-dimethylamino-2-methoxy-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-3-benzazepin-3-yl}-1-(4-methyl-piperazin-1-yl)-ethanone

HRID 167310Notes

Reaction equation

HRID 167310 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:18][CH3:19])[cH:11][c:12]([N:15]([CH3:16])[CH3:17])[cH:13][cH:14]2)[n:7]1.[NH2:21][c:22]1[cH:23][c:24]2[c:25]([cH:41][c:42]1[O:43][CH3:44])[CH2:26][CH2:27][N:28]([CH2:31][C:32](=[O:33])[N:34]1[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]1)[CH2:29][CH2:30]2>>[c:2]1([NH:21][c:22]2[cH:23][c:24]3[c:25]([cH:41][c:42]2[O:43][CH3:44])[CH2:26][CH2:27][N:28]([CH2:31][C:32](=[O:33])[N:34]2[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]2)[CH2:29][CH2:30]3)[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:18][CH3:19])[cH:11][c:12]([N:15]([CH3:16])[CH3:17])[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 672636672-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-3-benzazepin-3-yl)-1-(4-methyl-piperazin-1-yl)-ethanoneHCID 86634017N(1)-(2,5-Dichloro-pyrimidin-4-yl)-2-methoxy-N(4),N(4)-dimethyl-benzene-1,4-diamine

Product 1

HCID 668305142-{7-[5-Chloro-4-(4-dimethylamino-2-methoxy-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-3-benzazepin-3-yl}-1-(4-methyl-piperazin-1-yl)-ethanone

Sources & evidence

ORD record
ord-a9c0c73a96874629b9de4d8c1946b848
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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