Bromine → 2-Bromo-2'-chloroacetophenone

HRID 1673111Notes

Reaction equation

HRID 1673111 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

Product 1

HCID 27357852-Bromo-2'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (3.8 mL, 65 mmol) was added dropwise to a solution of 1-(2-chloro-phenyl)-ethanone (10 g. 65 mmol) in acetic acid (75 mL) at 0° C. The mixture was then warmed to room temperature and stirred overnight. The mixture was evaporated to dryness and used in the next step without further purification.

Workup

  1. customThe mixture was evaporated to dryness
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-e0007d841d324b3d907bbe8109f7e380
Source dataset
uspto-grants-2011_08
Patent number
US07999113B2

Reaction notes

Loading…