関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 5-Acetylthiophene-2-carboxylic acid (2-amino-3-carbamoylphenyl)amide | HCID 67353795 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(5-acetylthiophen-2-yl)-1H-benzimidazole-4-carboxamide | HCID 67352032 | 95.1% |
反応手順
To a solution of EXAMPLE 41A (1.70 g) in hot N,N′-dimethylformamide (60 mL) was added acetic acid (50 mL) and the solution heated at 125° C. for 3 hours. After cooling, the solution was filtered, and the yellow solid washed with methanol and dried to give the title compound (1.52 g, 95%). MS (APCI): 286 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07999117B2 |
|---|
| 出典データセット | uspto-grants-2011_08 |
|---|
| ORD ID | ord-0f80c83668ed49169fc1c8c0b2f6ecf5 |
|---|
| 出典メモ | uspto-grants-2011_08 |
|---|
