Dimethyl Sulfoxide → HCID 63802010, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-fluorophenylthiol (0.86 ml, 8.06 mmol) and K2CO3 (2.50 g, 18.12 mmol) in DMSO (5 ml) was added 2-fluorobenzaldehyde (1.00 g, 8.06 mmol) under N2 and the mixture heated at 100° C. for 3 hours. The reaction was cooled to room temperature and water (20 ml) added. This mixture was extracted with ethyl acetate, the combined organic extracts were washed with saturated brine, dried over MgSO4 and concentrated in vacuo to give a yellow solid (1.20 g, 5.17 mmol, 64%) δH (300 MHz, d6-DMSO) 10.23 (1H, s, CHO), 7.98 (1H, dd, J 7.3 and 1.7 Hz, Ar), 7.63-7.49 (3H, m, Ar), 7.45-7.32 (3H, m, Ar) and 6.88 (1H, d, J 7.7 Hz, Ar).

Provenance & Evidence