Benzylamine → HCID 67337539, compound

HRID 1673177Notes

Reaction equation

HRID 1673177 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C@H:7]([C@H:12]1[CH2:14][O:13]1)[CH2:6][CH2:5]2.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CO>[C:16]1([CH2:15][N:22]=[CH:14][C@H:12]([C@@H:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=3)[O:8]2)[OH:13])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 51698391(+)-(S,R)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

Product 1

HCID 67337539HCID 67337539, compoundYield 65.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-6-fluoro-3,4-dihydro-2-((R)-oxiran-2-yl)-2H-chromene (30 mg, 0.154 mmol) was dissolved in methanol (2 ml) and kept under stirring. benzylamine (40 mg, 0.374 mmol) was added and the reaction mixture left to stir. After checking the reaction outcome, the solution was concentrated under reduced pressure and the crude residue further dried at 30° C. in vacuo to furnish 30 mg of (R)-2-(phenylmethylimino)-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol as a white solid (64% yield).

Workup

  1. waitthe reaction mixture left
  2. stirringto stir
  3. concentrationthe solution was concentrated under reduced pressure
  4. dry with materialthe crude residue further dried at 30° C. in vacuo

Sources & evidence

ORD record
ord-279696da5bf64749a57c24b5f9f7bd18
Source dataset
uspto-grants-2011_08
Patent number
US07999124B2

Reaction notes

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