Hydrochloric Acid → HCID 59202346, compound

Participants

Reaction Steps

To a mixed solution of 10 ml of THF and 10 ml of water, 6.5 g of the obtained 4-(2-propynyloxy)-2,3,5-trifluorobenzoic acid 2-propynyl ester and 2.0 g of lithium hydroxide monohydrate were added, followed by stirring at room temperature for 2 hours and further stirring at 50° C. for 2 hours. The reaction mixture obtained by concentration under reduced pressure until the entire volume was reduced to about half was acidified by adding hydrochloric acid and the obtained solid was collected by filtration. The solid was dried and washed with hexane, and 4.0 g of 4-(2-propynyloxy)-2,3,5-trifluorobenzoic acid was obtained.

Provenance & Evidence