Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | HCID 11298596 | HCID 11298596 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | HCID 67334059 | HCID 67334059 | 32% |
Reaction Steps
A mixture of intermediate 4.iii (0.12 g, 0.4 mmol), 6-methoxy-4-oxiranyl-quinoline (0.083 g, 0.4 mmol, prepared according to WO 00/78748), K2CO3 (0.08 g, 0.58 mmol) and LiClO4 (0.048 g, 0.46 mmol) in DMF (4 ml) was heated at 90° C. overnight. The mixture was poured into water and diluted with EA. The yield after work up and chromatography (EA:MeOH 9:1 containing 1% NH4OH) was 0.065 g (32% yield; beige foam).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07999115B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-a237cf4f90d944cfb64aa08463aef1e6 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
