Tetrahydrofuran → 6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2-methyl-2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-one

참여 물질

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To the product of Example 1 Step B (7.0 g, 18.6 mmol in THF (90 mL) was added MeMgBr (1.4 M in toluene/THF, 14 mL, 19.6 mmol). After stirring for 3 min, prop-1-enylmagnesium bromide (0.5 M in THF, 55.9 mL, 28 mmol) was added and the temperature was increased to 50° C. The reaction was quenched with 2 M HCl after 30 min and diluted with EtOAc. The solution was washed with brine, and concentrated The residue was purified by flash chromatography on silica gel gradient eluted with 0-35% EtOAc in hexane to afford the title compound. (LC-2) HPLC/MS: 418.2 (M+1), 420.2 (M+3); Rt=4.08 min.

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