Acetonitrile → HCID 59785897, compound

Participants

Reaction Conditions

Reaction Steps

To 6-(2-chlorophenyl)-5-(4-chlorophenyl)-3-propionylpyridin-2(1H)-one (350 mg, 0.940 mmol), was added isobutyraldehyde (0.384. mL, 4.23 mmol), pyrrolidine (0.117 mL, 1.41 mmol) and acetonitrile (1.5 mL) The reaction was heated in a CEM Discover microwave system to 90° C. in a sealed microwave tube for 50 min. An additional charge of isobutyraldehyde (0.4 mL, 4.4 mmol) was added and the reaction was heated by microwave to 100° C. for 25 min and then 110° C. for 25 min. The reaction was diluted with EtOAc and washed with brine. The reaction was concentrated and the residue was purified by flash chromatography on silica gel gradient eluted with 0-60% EtOAc in hexane to afford the title compound. (LC-2) HPLC/MS: 426.1 (M+1), 428.1 (M+3); Rt=4.45 min.

Provenance & Evidence