Acetic Anhydride → HCID 25060792, compound

Participants

Reaction Steps

To the product of Example 68 (25 mg, 0.0575 mmol) was added acetic anhydride (0.25 mL, 2.65 mmol) in pyridine (2 mL). The reaction was stirred 4 h and was concentrated. The residue was diluted with EtOAc and washed with 1 M aq HCl followed by saturated aq NaHCO3/1 M aq NaOH (1:1). The solution was dried (Na2SO4). The concentrated residue was purified by flash chromatography on silica gel eluted with 50% EtOAc in hexane affording the title compound. (LC-2) HPLC/MS: 475.9 (M+1), 477.9 (M+3); Rt=4.29 min.

Provenance & Evidence