p-Toluenesulfonic acid monohydrate → HCID 67019962, compound

Participants

Reaction Conditions

Reaction Steps

To the product of Step A this example (192 mg, 0.382 mmol) was added p-toluenesulfonic acid monohydrate (72.6 mg, 0.276 mmol) in toluene (3 mL). The reaction was heated to 104° C. After 80 min the reaction was cooled and diluted with EtOAc. The solution was washed with brine and saturated aq NaHCO3. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-25% EtOAc in hexane affording the title compound as the faster eluting isomer on silica gel. (LC-2) HPLC/MS: 502.1 (M+1), 504.1 (M+3); Rt=4.52 min.

Provenance & Evidence