Potassium Hydroxide → HCID 67019966, compound

Participants

Reaction Conditions

Reaction Steps

To the product of Example 76 (46.5 mg, 0.127 mmol) was added KOH (10.3 mg, 0.184 mmol) in THF (1.5 mL), MeOH (0.2 mL) and water (0.075 mL). The reaction was heated to 50° C. After 27 min the reaction was cooled and diluted with EtOAc. The solution was washed with aq 2 M HCl and brine, dried (Na2SO4), filtered and concentrated to afford the product that was not purified further (LC-2) HPLC/MS: 476.0 (M+1), 478.0 (M+3); Rt=3.96 min.

Provenance & Evidence