Ethyl Bromide → HCID 25061301, compound

Participants

Reaction Steps

To the product of Example 68 (60 mg, 0.14 mmol) in DMF (1 mL) was added bromoethane (152 mg, 1.4 mmol) and NaH (6 mg, 0.14 mmol) and the suspension was stirred for 1 h at rt. The reaction was quenched by adding 1N HCl and water. The reaction was diluted with EtOAc, washed with a saturated aq NaHCO3 solution, brine, dried (Na2SO4), filtered and concentrated The residue was purified by flash chromatography on silica gel gradient eluted with 85% CH2Cl2 in hexane to afford the title compound. (LC-2) HPLC/MS: 462.2 (M+1), 464.2 (M+3); Rt=4.51 min

Provenance & Evidence