Tetrahydrofuran → HCID 86622718, compound

Participants

Reaction Steps

To the product of Example 3 (0.47 g, 1.2 mmol) in DMF (9 mL) at −78° C., was added 1 M LiHMDS in THF (1.3 mL, 1.3 mmol) and the reaction was stirred for 5 min. N-phenyl trifluoromethanesulfonamide (0.47 g, 1.3 mmol) was added and the reaction was allowed to come to rt. The reaction was stirred an additional 15 min, concentrated and the residue was purified by flash chromatography on silica gel gradient eluted with 0-20% EtOAc in hexane to afford the title compound. Step B: 7-(2-Chlorophenyl)-6-(4-chlorophenyl)-2,2-dimethyl-4-pyridin-4-yl-2H-pyrano[2,3-b]pyridine

Provenance & Evidence