Methyl iodide → HCID 67019918, compound

Participants

Reaction Steps

To the product (0.08 g, 0.15 mmol) from Step A in DMF (1 mL) at −78° C., was added 1 M LiHMDS in THF (0.19 mL, 0.19 mmol) and the reaction was stirred for 10 min. Iodomethane (0.05 mL, 0.77 mmol) was added and the reaction was allowed to come to rt. The reaction was stirred an additional 20 min. The reaction was diluted with EtOAc and washed with brine, dried (Na2SO4), filtered and evaporated. The residue was purified by flash chromatography on silica gel gradient eluted with 0-20% EtOAc in hexane.

Provenance & Evidence