Lawesson's reagent → HCID 86622719, compound

HRID 1673226Notes

Reaction equation

HRID 1673226 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][C:27](=O)[CH2:28][C:29](=[O:31])[CH3:30])[CH2:24][C:23]([CH3:34])([CH3:33])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:44])=CC=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][C:27](=[S:44])[CH2:28][C:29](=[O:31])[CH3:30])[CH2:24][C:23]([CH3:34])([CH3:33])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 86622720HCID 86622720, compound

Product 1

HCID 86622719HCID 86622719, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of the product of Step A (136 mg, 0.26 mmol) and Lawesson's reagent (106 mg, 0.26 mmol) in 5.0 mL of toluene was stirred at 120° C. for 3 h and then concentrated. Chromatography on a Biotage 40+S cartridge using 1:3 v/v EtOAc/hexanes as the eluant afforded the title compound.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-3962624cca3a47ac95ad5681a6bc1812
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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