Hydrazine → HCID 67019956, compound

HRID 1673231Notes

Reaction equation

HRID 1673231 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][C:27](=O)[O:28]C4C=CC=CC=4)[CH2:24][C:23]([CH3:37])([CH3:36])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1.[NH2:38][NH2:39]>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][C:27]([NH:38][NH2:39])=[O:28])[CH2:24][C:23]([CH3:37])([CH3:36])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86622722HCID 86622722, compound

Product 1

HCID 67019956HCID 67019956, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the product of Step A (77 mg, 0.14 mmol) and hydrazine (8.7 μL, 0.28 mmol) in 5.0 mL of EtOH was refluxed for 3 h. The reaction mixture was then concentrated to give the product, which was used directly in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. customto give the product, which
  3. customwas used directly in the next step without further purification

Sources & evidence

ORD record
ord-463824b5fbd84bc2b1dbb818180c5bd2
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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