Triethylamine → HCID 24993725, compound

Participants

Reaction Steps

A solution of Example 314 (840 mg, 1.45 mmol), palladium(II) acetate (16.3 mg, 0.07 mmol), dppf (81 mg, 0.15 mmol), and NEt3 (405 μL, 2.90 mmol) in 20 mL of CH3OH was stirred at 100° C. under 50 psi of CO for 24 h. After cooling to rt, the reaction mixture was filtered. The filtrate was concentrated and chromatography on a Biotage 25+M cartridge using 1:1 v/v EtOAc/hexanes as the eluant afforded the title compound: 1H NMR δ 1.46 (s, 3H), 1.49 (s, 9H), 1.54 (s, 3H), 1.82 (m, 1H), 2.29 (dd, J=6.2, 13.3, 1H), 3.90 (s, 3H), 4.89 (br. s, 1H), 5.12 (m, 1H), 7.01 (d, J=8.5, 2H), 7.16 (d, J=8.4, 2H), 7.40 (m, 1H), 7.73-7.92 (m, 3H).

Provenance & Evidence