Hydroxyamine hydrochloride → HCID 178426596, compound

Participants

Reaction Steps

A solution of Example 317 (120 mg, 0.24 mmol), hydroxylamine hydrochloride (65.6 mg, 0.94 mmol), and NaHCO3 (119 mg, 1.42 mmol) in 10 mL of EtOH was refluxed for 16 h. The reaction mixture was partitioned between brine (50 mL) and CH2Cl2 (50 mL). The aq layer was separated and extracted with CH2Cl2 (2×50 mL). The organic layers were combined, dried over MgSO4, and concentrated to give the product, which was taken into the next step without further purification.

Provenance & Evidence