Water → HCID 67019951, compound

Participants

Reaction Steps

To a solution of the product of Step A (9.5 g, 20.7 mmol) in 50 mL of THF was added 2.5 mL of H2O and 31.0 mL of trimethylphosphine in THF (1.0 M, 31.0 mmol). After stirring at rt for 3 h, the solvent was evaporated. Chromatography on a Biotage 40+M cartridge using 1:19 v/v CH3OH/CH2Cl2 as the eluant afforded the product: 1H NMR δ 1.42 (s, 3H), 1.54 (s, 3H), 1.78 (t, J=12.5, 1H), 2.18 (dd, J=5.9, 13.4, 1H), 4.16 (dd, J=6.0, 11.7, 1H), 7.04 (d, J=8.5, 2H), 7.17-7.26 (m, 5H), 7.93 (s, 1H).

Provenance & Evidence